Pediatric Research in Inpatient Settings Network


The Pediatric Research in Inpatient Settings (PRIS) network (pronounced 'PRIZE') is a research network whose mission is to improve the health of and healthcare delivery to hospitalized children and their families. PRIS was founded in 2001 and includes nearly 500 hospitalists from 50 pediatric centers across the United States and Canada. It is believed to be the largest pediatric inpatient research network in the world. PRIS strives to conduct research that is informative, relevant, and addresses real-world systems-based and clinical management decisions for hospitalized children with acute and chronic conditions. It is also concerned with developing strategies for implementing the results of comparative effectiveness research to produce better outcomes and value for hospitalized children and their families. It is governed by an Executive Committee made up of leading pediatric hospitalist-investigators and has Ex-Officio Members from four national organizations—the Child Health Corporation of America (CHCA), the Academic Pediatric Association (APA), the Society of Hospital Medicine (SHM), and the American Academy of Pediatrics (AAP). PRIS also has an Advisory Committee that includes representatives from organizations at the forefront of quality improvement, including Intermountain Healthcare (Dr. Brent James), the Institute for Healthcare Improvement, and the National Initiative for Children's Healthcare Quality (Dr. Charles Homer).

Much of the early work of PRIS investigators addressed the tremendous variation across hospitals in the processes and outcomes of care for a variety of acute and chronic pediatric conditions, including urinary tract infections (UTIs), osteomyelitis, Henoch Schonlein Purpura, complicated pneumonia, gastroesophageal reflux disease, and others. The reduction of regional variation in care through identification of best practices and standardization of care is likely to improve outcomes and reduce costs, and this goal has been featured as a critical component of healthcare reform. In pediatric hospital care, much of the unwarranted regional variation can be attributed to the paucity of comparative effectiveness evidence available to inform evidence-based guidelines. PRIS is committed to performing rigorous comparative effectiveness studies to address this unwarranted variation. When evidence exists, PRIS aims to test the reliable implementation of evidence across hospitals and measure the effect on patient outcomes.

PRIS is an open network that welcomes the participation of hospitalists and hospitals across the United States and Canada. We believe that collaborative research and implementation efforts are the key to transforming our healthcare system and improving outcomes for children. Our network is diverse, including small community hospitals and large freestanding community hospitals. Our hospitals' patients include a substantial number of racial and ethnic minorities. We also serve a high percentage of patients with multiple chronic complex conditions.