Pediatric Research in Inpatient Settings Network

Patrick Conway, MD, MSc

ConwayDr. Conway is Chief Medical Officer for the Centers for Medicare & Medicaid Services (CMS) and Director of the Office of Clinical Standards and Quality. This office is responsible for all quality measures for CMS, quality improvement programs in all 50 states, clinical standards, and all coverage decisions for treatments and services for CMS. The office budget exceeds $1.3 billion. Previously, he was Director of Hospital Medicine and an Associate Professor at Cincinnati Children's Hospital. He was also AVP Outcomes Performance, responsible for leading measurement, including the electronic health record measures, and facilitating improvement of health outcomes across the $1.5 billion health care system, including all Divisions and Institutes. Previously, he was Chief Medical Officer at the Department of Health and Human Services (HHS) in the Office of the Assistant Secretary for Planning and Evaluation. In 2007-08, he was a White House Fellow assigned to the Office of Secretary in HHS and the Director of the Agency for Healthcare Research and Quality. As Chief Medical Officer, he had a portfolio of work focused primarily on quality measurement and links to payment, health information technology, and policy, research, and evaluation across the entire Department. He also served as Executive Director of the Federal Coordinating Council on Comparative Effectiveness Research coordinating the investment of the $1.1 billion for CER in the Recovery Act. He was a Robert Wood Johnson Clinical Scholar and completed a Master's of Science focused on health services research and clinical epidemiology at the University of Pennsylvania and Children's Hospital of Philadelphia. Previously, he was a management consultant at McKinsey & Company, serving senior management of mainly health care clients on strategy projects. He has published articles in journals such as JAMA, New England Journal of Medicine, Health Affairs, and Pediatrics and given national presentations on topics including health care policy, quality of care, comparative effectiveness, hospitalist systems, and nurse staffing. He is a practicing pediatric hospitalist, completed pediatrics residency at Harvard Medical School's Children's Hospital Boston, and graduated with High Honors from Baylor College of Medicine. He is married with two children.

Ron Keren, MD, MPH

KerenDr. Keren is a pediatric hospitalist and researcher who studies the effectiveness and cost-effectiveness of treatments for common diseases of childhood, such as neonatal jaundice, influenza, and urinary tract infections. His research has been funded by NIH, AHRQ, CDC, PCORI, as well as other foundation grants. He is currently the principal investigator on three R01 grants including a multi-center randomized controlled trial of antibiotic prophylaxis for children with VUR (RIVUR study), a prospective cohort study of children with history of urinary tract infection but no VUR (CUTIE study), and a project to merge clinical and administrative data from six large children's hospitals for the performance of comparative effectiveness research (PROSPECT). Additionally, Dr. Keren is PI on a PCORI grant comparing the effectiveness of two treatment options for serious bacterial infections in children.

Dr. Keren studied philosophy at Princeton University and medicine at the NYU School of Medicine. He completed his pediatric residency at the University of California, San Francisco, where he also served as chief resident. He received a Master of Public Health at Harvard University while completing a health services research fellowship at Childrens Hospital Boston. Dr. Keren received the 2012 SHM Research Award. In his spare time, he cycles, swims, and runs in preparation for the short triathlons that he occasionally attempts to survive.

Christopher P. Landrigan, MD, MPH

Landrigan Christopher P. Landrigan, MD, MPH is Research Director of the Inpatient Pediatrics Service at Boston Children’s Hospital, Director of the Sleep and Patient Safety Program at Brigham and Women’s Hospital, and Associate Professor of Pediatrics and Medicine at Harvard Medical School. Chris did his internship, residency, and fellowship at Boston Children’s from 1995-2000, and has been working at Boston Children’s Hospital ever since, as a pediatric hospitalist and patient safety researcher.  In addition, Chris was the founding chair and is currently an Executive Council Member of the Pediatric Research in Inpatient Settings (PRIS) Network.
Chris has led numerous landmark studies on the epidemiology of medical errors and adverse events, and interventions designed to reduce their incidence.   His most important work has been focused on developing reliable patient safety measurement tools, and improving the organization of residency programs and academic medical centers.  His work on the relationship between resident work hours, sleep, and patient safety contributed to national changes in resident work hour standards.  More recently, concerned with improving communication in hospitals, he led the development of I-PASS, a multi-faceted teamwork and handoff improvement program.  He has authored over 100 publications in the medical literature, including more than a dozen in the New England Journal of Medicine and JAMA.  He has received numerous awards for his research, teaching, leadership, and innovation.

Sanjay Mahant, MD, MSc, FRCPC

MahantDr. Mahant is a Staff Pediatrician in the Division of Paediatric Medicine, Hospital for Sick Children (SickKids), Toronto and Assistant Professor, Department of Paediatrics, University of Toronto. He completed his medical degree at the University of Toronto and pediatric residency at SickKids. He received his MSc in health research methods at McMaster University, Canada and is a member of the Paediatric Outcomes Research Team (PORT) in the Division of Paediatric Medicine at SickKids. His clinical focus is primarily in the care of hospitalized children and children with complex chronic conditions. His research and scholarly interests have focused on (1) the study of families and children with chronic complex conditions and specifically around feeding interventions in neurologically impaired children (2) the study of common conditions (diagnosis, treatment, outcomes) seen on the inpatient unit including urinary tract infections and complicated pneumonia (3) and quality improvement and clinical excellence.

Samir S. Shah, MD, MSCE

ShahDr. Shah is a Pediatric Hospital Medicine and Pediatric Infectious Diseases physician. He is Professor of Pediatrics at the University of Cincinnati College of Medicine. He is also Director of the Division of Hospital Medicine and holds the Cincinnati Children's Research Foundation Endowed Chair in Hospital Medicine at Cincinnati Children's Hospital Medical Center.

Dr. Shah's research focuses on improving the efficiency of care for hospitalized children with a focus on common serious infections such as pneumonia and meningitis. Ongoing projects include developing novel databases to conduct comparative effectiveness research, including merging clinical data with the Pediatric Health Information System (PHIS+) and merging the Society of Thoracic Surgeons Congenital Heart Database with the Pediatric Health Information System (STS-PHIS). His current research support includes funding from the Agency for Healthcare Research and Quality, the Patient-Centered Outcomes Research Institute, and the Children's Hospital Association. Dr. Shah was Associate Chair of the National Pneumonia Guidelines Committee, jointly sponsored by the Infectious Diseases Society of America and the Pediatric Infectious Diseases Society. He is a Deputy Editor of the Journal of Hospital Medicine, an Associate Editor for the Journal of the Pediatric Infectious Diseases Society, and an editorial board member of Archives of Pediatrics & Adolescent Medicine. In addition, he is editor or co-editor of 8 books in the fields of pediatrics and infectious diseases including The Philadelphia Guide: Inpatient Pediatrics (Lippincott Williams & Wilkins, 2005), and Pediatric Practice: Infectious Diseases (McGraw-Hill Medical, 2009), an infectious diseases textbook written for the pediatric hospitalist. Dr. Shah has received several prestigious research awards, including the Pediatric Infectious Diseases Society Young Investigator Award and the Society of Hospital Medicine Excellence in Research Award.

Raj Srivastava, MD, MPH

SrivastavaRaj Srivastava, MD, FRCP(C), MPH, is the Assistant Vice President of Research at Intermountain Healthcare, a system-wide role, and the Medical Director of the Office of Research. He is also currently serving as the Vice-Chair of Research, Department of Medicine, Intermountain Medical Center, Intermountain Healthcare. He is a Professor of Pediatrics at the University of Utah in the Division of Inpatient Medicine. He trained at the Hospital for Sick Children in Toronto where he was an Associate Chief Resident, and completed a Fellowship in Health Services Research at Children’s Hospital, Boston, Harvard Medical School.

Dr. Srivastava is a practicing hospitalist at Primary Children’s Hospital in Salt Lake City. In addition, he is the past-Chair of the only funded hospitalist network, Pediatric Research in Inpatient Settings (PRIS). PRIS is a > 100 hospital research and implementation network conducting several large multi-center studies that are important to the field of Hospital Medicine – including prioritizing high priority pediatric conditions that are costly, prevalent and demonstrate high inter-hospital variation in cost per admission; building data infrastructure for Comparative Effectiveness Research (CER); performing pediatric CER studies; and studying system-level interventions using quality improvement methods to improve patient safety.

Karen M. Wilson, MD, MPH

WilsonDr. Wilson received her undergraduate degree in psychology from St. Lawrence University, and a Master’s in Public Health, and MD with Distinction in Research from the University of Rochester.  She completed her Pediatric Residency and Academic General Pediatric fellowship also at the University of Rochester.  She is currently the Section Head for Pediatric Hospital Medicine at Children’s Hospital, Colorado, and an Associate Professor of Pediatrics at the University of Colorado, Denver.  Her primary research interests are in understanding the relationship between secondhand tobacco smoke exposure and severity of illness in children hospitalized for respiratory illness, and how to improve outcomes in hospitalized children.  Dr. Wilson has an R01 from NCI to study an inpatient parent smoking cessation intervention, and she is one of the Principal Investigators and on the Speaker’s Bureau of the AAP/Julius B. Richmond Center of Excellence, which is dedicated to eliminating children’s exposure to tobacco and secondhand smoke.  In addition, she is the Chair of the AAP’s Section on Tobacco Control, and Research Chair for the Academic Pediatric Association.  Dr. Wilson is also an Executive Council member of the Pediatric Research in Inpatient Settings Network, and Deputy Editor of Hospital Pediatrics.

Jay Berry, MD, MPH

BerryDr. Berry is an Assistant Professor of Pediatrics at Boston Children's Hospital and Harvard Medical School. As a general pediatrician and hospitalist, he coordinates care for children with complex medical problems and needs. Dr. Berry's quality improvement initiatives and health services research have focused on optimizing health outcomes and reducing unnecessary resource utilization for children with medical complexity through proactive care planning, integrated health information management, high quality discharge planning, and use of home and post-acute care services. His work has been published in JAMA, BMJ, Health Affairs, and PLoS Medicine. He is the recipient of the Young Clinician Research Award given by the Center for Integration of Medicine and Innovative Technology, the Outstanding Achievement for Scientific Contribution Award given by the Agency for Healthcare Research and Quality, and the Nemours Child Health Services Research Award. Dr. Berry has received prior and on-going research support from the Agency For Healthcare Research and Quality, National Institute for Child Health and Human Development, Maternal Child Health Bureau, Cardinal Health Foundation, Lucile Packard Foundation for Children's Health, and European Commission.

Lisa McLeod, MD, MSCE

McLeod Dr. McLeod is a pediatric hospitalist at Children’s Hospital Colorado, with a faculty appointment in the University of Colorado Adult and Child Consortium on Health Outcomes and Delivery Sciences (ACCORDS). She received her medical degree from Harvard Medical School and completed her pediatric residency training at Children’s Hospital of Philadelphia. Following residency she received a Master’s in Clinical Epidemiology from the University of Pennsylvania Center for Biostatistics and Epidemiology.

Dr. McLeod’s research focus is comparative effectiveness and outcomes research in inpatient surgical care. She is currently Principal Investigator on an AHRQ PCOR K99/R00 multi-center study of surgical site infection prevention and systems barriers to effective care in children undergoing spinal fusion surgery. She has had numerous publications and invited presentations related to spine surgery research for both general pediatric and surgical audiences, and serves as chair of the research committee for the multi-disciplinary AAP surgical comanagement sub-committee.

Christopher P. Bonafide, MD, MSCE

Bonafide Dr. Bonafide is a pediatric hospitalist at The Children’s Hospital of Philadelphia and an Assistant Professor of Pediatrics at the University of Pennsylvania. His research focuses on discovering the best ways to identify deteriorating patients in the hospital, and the best mechanisms to respond to those patients. He is also interested in identifying unintended consequences of interventions intended to improve patient safety. Dr. Bonafide has investigated these areas using a wide range of study designs and methods. He is currently funded by a Career Development Award from NHLBI focused on measuring alarm fatigue— a significant barrier to promptly recognizing clinical deterioration— from physiologic monitoring devices. He also holds a Young Investigator Award from the Academic Pediatric Association focused on evaluating an intervention to reduce unnecessary monitor alarms in hospitalized children. In addition, Dr. Bonafide co-directs a pediatric hospital medicine research fellowship at The Children’s Hospital of Philadelphia funded by NICHD, the Pediatric Hospital Epidemiology and Outcomes Training (PHEOT) Program. In addition to his publications in journals such as JAMA Pediatrics, Journal of the American Medical Informatics Association, and Pediatrics, his work has recently been featured on National Public Radio and in The Wall Street Journal. Dr. Bonafide serves as an Associate Editor of the Journal of Hospital Medicine and is an Editorial Board Member of a new journal, Pediatric Quality and Safety.

Theoklis Zaoutis, MD, MSCE

Theoklis Zaoutis, MD, MSCE, is the Werner and Gertrude Henle Professor of Pediatrics and Professor of Epidemiology at the Perelman School of Medicine at the University of Pennsylvania (PENN) and Chief of the Division of Infectious Diseases at the Children’s Hospital of Philadelphia (CHOP). He also serves as the Director for the Center for Pediatric Clinical Effectiveness (CPCE) at the CHOP Research Institute. The mission of the CPCE is to discover, disseminate, and implement knowledge about best practices in pediatrics.

At Penn, he is Senior Scholar in the Center for Clinical Epidemiology and Biostatistics at PENN, where he serves as the director of the Master of Science in Clinical Epidemiology degree program at PENN.

He is the author of over 230 peer-reviewed publications, most of which are in pediatric infectious diseases with a focus on healthcare acquired infections, antimicrobial resistance, and antimicrobial use.

Dr. Zaoutis is currently the principal investigator for a National Institute for Allergy and Infectious Diseases (NIAID) contract, which supports a randomized placebo controlled trial of short course antibiotic therapy for urinary tract infections in children as a strategy to reduce antimicrobial resistance.  He also serves as co-PI of the first large resource study to be conducted by the newly formed Antimicrobial Leadership Group of NIAID  focusing on the treatment of community-acquired pneumonia. In the past, he served as PI of an Agency for Healthcare Research and Quality (AHRQ) funded cluster-randomized trial of an antimicrobial stewardship intervention.

Dr. Zaoutis currently serves on the following national and international committees that relate to antimicrobial resistance:

  1. Vice-Chair, Pediatric Special Emphasis Panel, Antimicrobial Leadership Group of NIAID. He will assume the responsibility of chair in December of 2016.
  2. The Centers for Disease Control and Prevention’s Office of Infectious Disease Board of Scientific Counselors’Antimicrobial Resistance Working Group, NIAID’s Antimicrobial Resistance Leadership Group.
  3. The Antibiotic Resistance and Prescribing in European Children Working Group
  4. AAP’s Committee on Infectious Diseases (Red Book Committee).

He has served as an expert consultant for the CDC for Hospital-based Antimicrobial Surveillance, on the Best Pharmaceuticals for Children Act Prioritization Meeting NICHD Expert Review Panel, as a co-investigator at the PENN Centers for Education on Research and Therapeutics administered by AHRQ; and an Associate Editor for Pharmacoepidemiology and Drug Safety.

He is Editor-in-Chief of the Journal of the Pediatric Infectious Diseases Society. He also serves as the Director for the Center for Pediatric Clinical Effectiveness (CPCE) at the CHOP Research Institute. The mission of the CPCE is to discover, disseminate, and implement knowledge about best practices in pediatrics. In 2009, he was received the Society for Healthcare Epidemiology of America Pediatric Investigator Award. Finally, in 2015, he received the Pediatric Infectious Diseases Society Distinguished Service Award.


Patrick Brady, MD, MSc

Patrick Brady, MD, MSc is Associate Professor at the University of Cincinnati College of Medicine and an attending physician at Cincinnati Children's Hospital Medical Center. He is a hospital-based pediatrician, improvement scientist and health services researcher with a focus on designing and evaluating a highly reliable system to predict, identify, and intervene on hospitalized patients at risk of clinical deterioration. Specifically he uses situation awareness and other high-reliability strategies to leverage the expertise of patients, and families and front-line clinicians as well as big data to improve communication, shared understanding and the safety of care. He has completed fellowship training in clinical research and improvement science. In recent work, Dr. Brady and his team have developed, tested, and implemented standardized communication and huddles (short and structured briefings between nurses and physicians) to discuss high-risk patients. This has led to a significant and sustained reduction in unrecognized clinical deterioration and serious safety events among hospitalized children at our hospital. He has experience with quantitative methods using machine-learning methods to predict clinical deterioration and qualitative methods, including previous funded and published work where nurses, respiratory therapists, and resident physicians identified the enablers and barriers to situation awareness. With Dr. Chris Bonafide, he co-chairs the Pediatric Committee of the iSRRS. He has over 30 peer-reviewed publications. He has a K08 career development award from AHRQ which aims to understand how families of hospitalized children identify a worsening condition or illness and communicate their concerns to the healthcare team, and then to partner with families and clinicians to co-design and test communication tools to improve shared understanding and reduce medical errors.